Promethazine suppositories are for rectal use only. Don't try and swallow the suppositories or insert in every other part of One's body.
This medication has been prescribed for your present-day issue only. Tend not to use it later on for one more affliction Except if explained to to do so by your medical doctor. A unique medication may very well be needed in those scenarios.
Tend not to flush prescription drugs down the rest room or pour them into a drain Except instructed to take action. Correctly discard this solution when it is actually expired or no longer necessary. Consult your pharmacist or local squander disposal firm.
Also tell your health care provider and pharmacist Should you have at any time experienced an abnormal or unforeseen reaction once you took promethazine, another phenothiazine, or almost every other medication. Question your physician or pharmacist if you do not know if a medication you are allergic to is often a phenothiazine.
Check with the wellness treatment Experienced if any of the subsequent Unwanted side effects continue on or are bothersome or Should you have any questions on them:
In case you think that you or anyone near you is demonstrating indications of habit, you are able to Call the next corporations for fast aid and assistance:
While you are taking this medication, it is especially vital that your Health care professional know For anyone who is using any with the medicines shown under. The following interactions happen to be selected on The idea of their probable significance and therefore are not always all-inclusive.
The concomitant utilization of Promethazine with Codeine Oral Alternative with all cytochrome P450 3A4 inducers or discontinuation of a cytochrome P450 3A4 inhibitor may end in reduced codeine ranges, higher norcodeine levels, and fewer metabolism by means of 2D6 with resultant lessen morphine degrees. This may be connected to a minimize in efficacy, and in a few sufferers, may perhaps result in symptoms and symptoms of opioid withdrawal.
When used for an prolonged time, this medication may not perform in addition and may call for distinct dosing. Talk to your physician if this medication stops Doing work effectively.
Because opioid agonists may possibly raise biliary tract stress, with resultant rise in plasma amylase or lipase concentrations, willpower of these enzyme levels could be unreliable for twenty-four several hours just after administration of a dose of Promethazine with Codeine Oral Alternative.
A perhaps deadly symptom advanced from time to time known as Neuroleptic Malignant Syndrome (NMS) has become claimed in association with promethazine HCl on your own or together with antipsychotic medicines.
Codeine has minimal plasma protein binding with about seven to twenty five% of codeine sure to plasma proteins. Codeine passes the blood brain barrier and also the placental barrier. Small quantities of codeine and its metabolite, morphine, are transferred to human breast milk.
Opioid-induced infant deaths have occurred from breastfeeding by mothers who were ultrarapid metabolizers using codeine postpartum. Conversely, poor metabolizers may practical experience weak discomfort aid when addressed with codeine. The presence of the methyl group about the Promethazine codeine syrup number 3 carbon limitations the 1st-move presystemic metabolism of codeine while in the liver.
Postmarketing cases of respiratory depression, which includes fatalities have been claimed with utilization of promethazine in pediatric sufferers.